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Your Vote Counts! MINERVA NEUROSCIENCES, INC. 2023 Annual Meeting Vote by September 26, 2023 11:59 PM ET MINERVA NEUROSCIENCES, INC. 1500 DISTRICT AVE BURLINGTON, MA 01803 V20605-P97519 You invested in MINERVA NEUROSCIENCES, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the 2023 Annual Meeting of Stockholders to be held on September 27, 2023. Get informed before you vote View the Notice and Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to September 13, 2023. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. The record date for the Annual Meeting is August 1, 2023. Only stockholders at the close of business on that date may vote at the meeting or any adjournment thereof. A list of stockholders as of the record date will be accessible electronically during the Annual Meeting at when you enter your 16-digit control number. For complete information and to vote, visit Control # Smartphone users Point your camera here and vote without entering a control number Vote Virtually at the Meeting* September 27, 2023 9:00 AM EDT Virtually at: *Please check the meeting materials for any special requirements for meeting attendance.


Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters. Board Voting Items Recommends 1. Election of Directors Nominees: 01) David Kupfer For 02) Jan van Heek 2. To approve an amendment to the Company’s Amended and Restated 2013 Equity Incentive Plan to, among other For things, increase the aggregate number of shares of common stock authorized for issuance under the plan by 700,000 shares. 3. To approve, on an advisory basis, the compensation of the Company’s named executive officers. For 4. To ratify the selection of Deloitte & Touche LLP as the Company’s independent registered public accounting firm for the For fiscal year ending December 31, 2023. NOTE: Such other business as may properly come before the meeting or any adjournment thereof. Prefer to receive an email instead? While voting on, be sure to click “Delivery Settings”. V20606-P97519